• Skip to main content
  • Skip to footer

PHYOX Clinical Trial Engagement Website | Dicerna Pharmaceuticals

  • About Primary Hyperoxaluria
  • Our Clinical Trials
    • PHYOX7
    • PHYOX8
  • Resources
  • FAQs
  • English
    • Français (French)
    • Deutsch (German)
    • Español (Spanish)
    • Italiano (Italian)
    • Română (Romanian)

Seeking Patients With Kidney Impairment Due to PH

Local researchers are seeking patients of all ages with severe renal (kidney) impairment due to primary hyperoxaluria (PH) for a clinical trial.

You may be interested in the PHYOX™ clinical trial program, a series of research studies evaluating a new investigational medicine called nedosiran, formerly DCR-PHXC, for the treatment of patients with PH.

For more information on the trial, visit clinicaltrials.gov and enter the identifier number NCT04580420, or click on the following link: https://clinicaltrials.gov/ct2/show/NCT04580420

Residents of the EU can visit EudraCT and enter the identifier number 2020-002826-97.  

See if You or a Loved One Qualifies!


To participate in the PHYOX7 study, patients must:

  • Have been diagnosed with PH by a physician, confirmed by genotyping
  • Have severe renal impairment
  • Have no history of systemic oxalosis
  • Either have no history, or a history of 18 months or less receiving dialysis

If you or someone you love has PH and you would like to learn more about the PHYOX™ clinical trials, fill out the form below.

A study representative will contact you and answer any questions you may have. Your information will only be used for the purpose of this study, unless authorized otherwise.

What to Expect

Potential patients will be screened over a period lasting no longer than 6 weeks. Qualified patients will be enrolled into the study.

Patients will receive monthly doses of nedosiran over the course of 42 months. The first 6 months are known as the primary treatment period. Upon successful completion of this period including the Day 180 visit, participants will continue for 3 years or until nedosiran is commercially available, whichever comes first.

About Primary Hyperoxaluria

Primary hyperoxaluria (PH) is a family of severe, ultra-rare, genetic liver disorders characterized by the overproduction of oxalate, a natural chemical in the body that is normally eliminated as waste through the kidneys. For more information on PH, click here.

About Dicerna

Dicerna Pharmaceuticals, Inc., a Novo Nordisk company, is focused on discovering, developing and commercializing medicines that are designed to leverage ribonucleic acid interference (RNAi) to silence selectively genes that cause or contribute to disease. Between Dicerna and our collaborative partners, we currently have more than 20 active discovery, preclinical or clinical programs focused on cardiometabolic, viral, chronic liver and complement-mediated diseases, as well as neurodegenerative diseases and pain.

For more information on Dicerna’s Privacy Policy, click here.

Safety Information

Nedosiran, formerly DCR-PHXC, is an investigational drug intended for the treatment of patients with PH. Investigational drugs are medicines that have not yet been approved by appropriate regulatory agencies. The safety and efficacy for nedosiran has not been established yet. Current and future studies are evaluating the safety and efficacy for nedosiran.

©2021 Dicerna Pharmaceuticals, Inc. / Lexington, MA

Footer

Safety Information

Nedosiran, formerly DCR-PHXC, is an investigational drug intended for the treatment of patients with PH. Investigational drugs are medicines that have not yet been approved by appropriate regulatory agencies. The safety and efficacy for nedosiran has not been established yet. Current and future studies are evaluating the safety and efficacy for nedosiran.

©2021 Dicerna Pharmaceuticals, Inc. / Lexington, MA

MED-ALL—000011 v2.0

  • About PH
  • Our Clinical Trials
    • PHYOX7
    • PHYOX8
  • Resources
  • FAQ
  • Glossary of Terms
  • Privacy Policy
  • Cookies Policy

Select your language:

  • English
  • Français
  • Deutsch
  • Italiano
  • Română
  • Español
This website uses strictly necessary cookies to enable the website to function.

If you agree we would also like to use non-essential cookies to enable us to observe traffic levels to the website, to improve the quality of your experience when visiting our website, and to show you relevant advertisements. For more information, including on the third parties who use cookies on our website, please see our Cookie Policy
Cookie settingsACCEPT
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checbox-analytics1 yearThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checbox-functional1 yearThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checbox-others1 yearThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-advertisement1 yearThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertisement".
cookielawinfo-checkbox-necessary1 yearThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance1 yearThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy6 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
CookieDurationDescription
DRIVE_STREAMsessionThis cookie is set by Google Drive. This cookie allows Google Drive video player to obtain correct file from its cloud storage.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
CookieDurationDescription
_gat1 minuteThis cookies is installed by Google Universal Analytics to throttle the request rate to limit the colllection of data on high traffic sites.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
CookieDurationDescription
_ga1 yearsThis cookie is installed by Google Analytics. The cookie is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. The cookies store information anonymously and assign a randomly generated number to identify unique visitors.
_gid1 dayThis cookie is installed by Google Analytics. The cookie is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visted in an anonymous form.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
CookieDurationDescription
NID6 monthsThis cookie is used to a profile based on user's interest and display personalized ads to the users.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
Save & Accept